prof. dr. L.S. (Linda) de Vries

Full Professor
prof. dr. L.S. (Linda) de Vries
  • Birth Center Neonatology - Medical



Linda de Vries obtained her PhD degree in Utrecht (1987) with Leo van de Brande. The degree was based on data collected during a 4 year research period at the Hammersmith Postgraduate school in London where she worked with Lilly and Victor Dubowitz in the field of Neonatal Neurology. Between 1987 and 1989 she did her Pediatric Neurology fellowship in Leuven with Paul Casaer. Since 1989, she has worked in the department of Neonatology in Utrecht, where she is a professor in Neonatal Neurology since 2001.

Her research focuses on prediction of neurodevelopmental outcome in high risk preterm and full-term newborns, using neurophysiology and neuro-imaging methods.  These at risk children are also seen by her in the follow-up clinic until early childhood. She has a special interest in neonatal stroke and brain plasticity.  Her work has been published in >300 publications.


Research line

Neonatal Neurology

Most recent key publications

1: van de Aa NE, Benders MJNL, Vincken KL,Groenendaal F, de Vries LS, The course of apparent diffusion coefficient values following perinatal arterial ischemic stroke. PlosOne 2013;8(2):e56784
2: Haastert IC, Groenendaal F, Uiterwaal CSPM, Termote JUM, van der Heide-Jalving M, Eijsermans MJC, Gorter JW, Helders PJM, Jongmans MJ, de Vries LS. Decreasing incidence and severity of cerebral palsy in prematurely born children. J Pediatr 2011; 159:8
3: Van Rooij, LGM, Toet, MC , van Huffelen AC, Groenendaal F, Laan W, Zezic A, de Haan T, van Straaten ILM, Vrancken S, van Wezel G, van der Sluijs J, ter Horst H, Gavilanes D, Laroche S, Naulaers G, de Vries LS. Effect of treatment of subclinical neonatal seizures detected with continuous amplitude-integrated electroencephalographic monitoring: a randomised controlled Trial. Pediatrics. 2010;125:e358-66
4: de Vries LS, Koopman C, Groenendaal F, van Schooneveld M, Verheijen F, Verbeek E, WitkampTh D, van der Worp HB, Mancini GMS. COL4A1 mutation in two preterm siblings with antenatal onset of parenchymal hemorrhage. Annals Neurol 2009; 65:12-18
5: Pressler RM, Boylan GB, Marlow N, Blennow M, Chiron C, Cross JH, de Vries LS, Hallberg B, Hellström-Westas L, Jullien V, Livingstone V, Mangum B, Murphy B, Murray D, Pons G, Rennie J, Swarte R, Toet MC, Vanhatalo S, Zohar S, for the NEonatal seizure treatment with Medication Off -patent (NEMO)consortium Bumetanide for the treatment of seizures in newborn babies with hypoxic ischaemic encephalopathy (NEMO): an open-label, dose finding, and feasibility phase 1/2 trial. Lancet Neurology 2015 Mar 9. pii: S1474-4422(14)70303-5

Fellowship and Awards

  • 1: Honorary award of the German speaking society of Neuropediatrics (GNP) 2015
    2: ZonMW, co-applicant, Adult mesenchymal stem cells (MSC) to regenerate the neonatal brain (2011)
    3: EU-FP7, co-applicant, NEMO1: An open label exploratory dose finding and pharmacokinetic clinical trial of bumetanide for the treatment of NEonatal seizure using Medication Off-patent. (2010)
    4: Harwood Nash memorial lecture, Toronto, 2012
    5: McCance Lecture (British Neonatal Society), 2004
    6: Bruce Berg Visiting Professor Lecture (UCSF San Francisco), 2004

Research Output (620)

Association of early skin breaks and neonatal thalamic maturation:A modifiable risk?

Duerden Emma G, Grunau Ruth E, Chau Vann, Groenendaal Floris, Guo Ting, Chakravarty M Mallar, Benders Manon, Wagenaar Nienke, Eijsermans Rian, Koopman Corine, Synnes Anne, Vries Linda de, Miller Steven P 21 okt 2020, In: Neurology. 95 , p. e3420-e3427

A machine-learning algorithm for neonatal seizure recognition:a multicentre, randomised, controlled trial

Pavel Andreea M, Rennie Janet M, de Vries Linda S, Blennow Mats, Foran Adrienne, Shah Divyen K, Pressler Ronit M, Kapellou Olga, Dempsey Eugene M, Mathieson Sean R, Pavlidis Elena, van Huffelen Alexander C, Livingstone Vicki, Toet Mona C, Weeke Lauren C, Finder Mikael, Mitra Subhabrata, Murray Deirdre M, Marnane William P, Boylan Geraldine B 27 aug 2020, In: The Lancet. Child & adolescent health. 4 , p. 740-749 10 p.

Increased Use of Therapeutic Hypothermia in Infants with Milder Neonatal Encephalopathy due to Presumed Perinatal Asphyxia

Parmentier Corline E J, de Vries Linda S, Toet Mona C, van Haastert Ingrid C, Koopman Corine, Weeke Lauren C, Groenendaal Floris 19 aug 2020, In: Neonatology. 117 , p. 488-494 7 p.

Randomized Controlled Early versus Late Ventricular Intervention Study in Posthemorrhagic Ventricular Dilatation:Outcome at 2 Years

Cizmeci Mehmet N, Groenendaal Floris, Liem Kian D, van Haastert Ingrid C, Benavente-Fernández Isabel, van Straaten Henrica L M, Steggerda Sylke, Smit Bert J, Whitelaw Andrew, Woerdeman Peter, Heep Axel, de Vries Linda S, 12 aug 2020, In: The Journal of Pediatrics. 226 , p. 28-35.e2

Management of Post-hemorrhagic Ventricular Dilatation in the Infant Born Preterm

El-Dib Mohamed, Limbrick David D, Inder Terrie, Whitelaw Andrew, Kulkarni Abhaya V, Warf Benjamin, Volpe Joseph J, de Vries Linda S 30 jul 2020, In: The Journal of Pediatrics. 226 , p. 16-27.e3

Non-right-handedness in children born extremely preterm:Relation to early neuroimaging and long-term neurodevelopment

van Heerwaarde Alise A, van der Kamp Laura T, van der Aa Niek E, de Vries Linda S, Groenendaal Floris, Jongmans Marian J, Eijsermans Rian J C, Koopman-Esseboom Corine, van Haastert Inge-Lot C, Benders Manon J N L, Dudink Jeroen 6 jul 2020, In: PLoS ONE. 15

Increase in Brain Volumes after Implementation of a Nutrition Regimen in Infants Born Extremely Preterm

van Beek Pauline E, Claessens Nathalie H P, Makropoulos Antonios, Groenendaal Floris, de Vries Linda S, Counsell Serena J, Benders Manon J N L 7 mei 2020, In: The Journal of Pediatrics. 223 , p. 57-63.e5

Automated cot-side tracking of functional brain age in preterm infants

Stevenson Nathan J, Oberdorfer Lisa, Tataranno Maria-Luisa, Breakspear Michael, Colditz Paul B, de Vries Linda S, Benders Manon J N L, Klebermass-Schrehof Katrin, Vanhatalo Sampsa, Roberts James A 5 mei 2020, In: Annals of Clinical and Translational Neurology. 7 , p. 891-902 12 p.

Morphine affects brain activity and volumes in preterms:An observational multi-center study

Tataranno M L, Gui L, Hellström-Westas L, Toet M, Groenendaal F, Claessens N H P, Schuurmans J, Fellman V, Sävman K, de Vries L S, Huppi P, Benders M J N L 7 apr 2020, In: Early Human Development. 144 8 p.

Cerebral palsy after very preterm birth - an imaging perspective

Gano Dawn, Cowan Frances M, de Vries Linda S 6 apr 2020, In: Seminars in Fetal & Neonatal Medicine. 25 , p. 101106

All research output