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prof. dr. E.E.S. Nieuwenhuis

Full Professor

  • Gastroenterology & Hepatology research 1
  • Onderzoek

prof. dr. E.E.S. Nieuwenhuis

Biography

Edward Nieuwenhuis, pediatrician, obtained a PhD in mucosal immunology (Prof. Blumberg, Harvard University and Prof. Heijnen, Utrecht University). He became a paediatric gastroenterologist, focusing     on the innate immunesystem in Inflammatory Bowel Disease. His work includes the development of a enterocolitis model in Zebrafish. His current research focuses on IBD, somatic stemcells, epithelial biology and genetics.

In 2009, Edward Nieuwenhuis was appointed as Chairman of the Paediatrics Division of the Wilhelmina Children’s Hospital Utrecht , The Netherlands. In 2010, he was also appointed as Chairman of the    leading program (speerpunt) Child Health of  the University Medical Center Utrecht.

During this period, the Hospital has established strong alliances with medical centers and research institutes in the Netherlands (e.g. Maxima, national center for pediatric oncology, Hubrecht institute for developmental biology & stem cell research) and abroad (e.g. Boston Children’s, The Hospital for Sick Children, Toronto, Hospital Pablo Tobon Uribe, Medellin).

His goal is to build an integrated academic Children’s Hospital which provides health care, medical training and science of excellent standards.

Side Activities

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    2003 Chair CD1-NKT session 12th International Congress of Mucosal Immunology, Boston, USA

    2004-2009 Research Committee Erasmus MC-Sophia Children’s Hospital, Rotterdam

    2005-2009 Working Group Pediatric Allergic Diseases

    2006-2009 Chairman Committee on Clinical Nutrition Erasmus MC-Sophia Children’s Hospital

    2006-2009 Consultant for the International Immunity Advisory Board of Royal Numico

    2006-2009 Member Steering Committee for the Masters of Science program ‘Infection and Immunity’, Erasmus University, Rotterdam

    2007-2011 Scientific Advisor Committee for primary child care in the Netherlands

    2008-2009 Board member, MRACE, Erasmus University advisory committee

    2008-2014 Founder, CEO & CSO LipImmune

    2010- Member of the Board, Wilhelmina Research Fund, Utrecht

    2009- Member of the Local Board, Ronald McDonald Huis, Utrecht

    2010- Scientific Advisor Nutricia

    2010- Scientific Advisor Friso

    2011- Scientific Advisor International Congress of Mucosal Immunology, Paris, France,

    2011- Medical Advisor Health Council of the Netherlands (RGO)

    2011-2015 Editor-in-Chief Pediatric Journal 'Kinderarts&Wetenschap'

    2015- Cheif Editor 'Leerboek Kindergeneeskunde'

    Member, Society of Mucosal Immunology (SMI)

    Member, Dutch Society of Pediatrics (NVK)

    Board member, Dutch Society of Immunology (NVVI)

    Member, European Society of Ped Gastroenterology Hepatology and Nutrition (ESPGHAN)

     

     

Research Output (121)

AML Subtype Is a Major Determinant of the Association between Prognostic Gene Expression Signatures and Their Clinical Significance

Wiggers Caroline R M, Baak Mirna L, Sonneveld Edwin, Nieuwenhuis Edward E S, Bartels Marije, Creyghton Menno P 10 sep 2019, In: Cell Reports. 28 , p. 2866-2877.e5

Transcriptomic and Epigenomic Profiling of Histone Deacetylase Inhibitor Treatment Reveals Distinct Gene Regulation Profiles Leading to Impaired Neutrophil Development

Govers Anita M A P, Wiggers Caroline R M, van Boxtel Ruben, Mokry Michal, Nieuwenhuis Edward E S, Creyghton Menno P, Bartels Marije, Coffer Paul J aug 2019, In: HemaSphere. 3

Motor function impairment is an early sign of CLN3 disease

Kuper Willemijn F.E., Van Alfen Claudia, Van Eck Linda, Huijgen Barbara C.H., Nieuwenhuis Edward E.S., Van Brussel Marco, Van Hasselt Peter M. 16 jul 2019, In: Neurology. 93 , p. e293-e297

Integrated analysis of transcriptional regulation in PLN R14del cardiomyopathy

Pei J., Harakalova M., Nagyova E., Gho J. M. I. H., Sepehrkhouy S., van Dinter J., van Mil A., Buijsrogge M. P., de Jonge N., Huibers M. M., Nieuwenhuis E. E. S., den Ruijter H. M., Pasterkamp G., Doevendans P. A., Hajjar R., Mercola M., Sluijter J. P. G., de Weger R. A., Cheng C., Vink A., Mokry M., Asselbergs F. W. jul 2019, In: European Journal of Human Genetics. 27 , p. 790-791

Human Fetal TNF-α-Cytokine-Producing CD4+ Effector Memory T Cells Promote Intestinal Development and Mediate Inflammation Early in Life

Schreurs Renée R C E, Baumdick Martin E, Sagebiel Adrian F, Kaufmann Max, Mokry Michal, Klarenbeek Paul L, Schaltenberg Nicola, Steinert Fenja L, van Rijn Jorik M, Drewniak Agata, The Sarah-May M L, Bakx Roel, Derikx Joep P M, de Vries Niek, Corpeleijn Willemijn E, Pals Steven T, Gagliani Nicola, Friese Manuel A, Middendorp Sabine, Nieuwenhuis Edward E S, Reinshagen Konrad, Geijtenbeek Teunis B H, van Goudoever Johannes B, Bunders Madeleine J 19 feb 2019, In: Immunity. 50 , p. 462-476.e1-e8

Global transcriptional analysis identifies a novel role for SOX4 in tumor-induced angiogenesis

Vervoort Stephin J, de Jong Olivier G, Roukens M Guy, Frederiks Cynthia L, Vermeulen Jeroen F, Lourenço Ana Rita, Bella Laura, Vidakovic Ana Tufegdzic, Sandoval José L, Moelans Cathy, van Amersfoort Miranda, Dallman Margaret J, Bruna Alejandra, Caldas Carlos, Nieuwenhuis Edward, van der Wall Elsken, Derksen Patrick, van Diest Paul, Verhaar Marianne C, Lam Eric W-F, Mokry Michal, Coffer Paul J 3 dec 2018, In: eLife. 7

Megakaryocyte lineage development is controlled by modulation of protein acetylation

Bartels Marije, Govers Anita, Polak Roel, Vervoort Stephin, Van Boxtel Ruben, Pals Cornelieke, Bierings Marc, Van Solinge Wouter, Egberts Toine, Nieuwenhuis Edward, Mokry Michal, Coffer Paul James 26 apr 2018, In: PLoS ONE. 13

Intestinal Failure and Aberrant Lipid Metabolism in Patients With DGAT1 Deficiency

van Rijn Jorik M., Ardy Rico Chandra, Kuloğlu Zarife, Härter Bettina, van Haaften-Visser Désirée Y., van der Doef Hubert P.J., van Hoesel Marliek, Kansu Aydan, van Vugt Anke H.M., Thian Marini, Kokke Freddy T.M., Krolo Ana, Başaran Meryem Keçeli, Kaya Neslihan Gurcan, Aksu Aysel Ünlüsoy, Dalgıç Buket, Ozcay Figen, Baris Zeren, Kain Renate, Stigter Edwin C.A., Lichtenbelt Klaske D., Massink Maarten P.G., Duran Karen J., Verheij Joke B.G.M., Lugtenberg Dorien, Nikkels Peter G.J., Brouwer Henricus G.F., Verkade Henkjan J., Scheenstra René, Spee Bart, Nieuwenhuis Edward E.S., Coffer Paul J., Janecke Andreas R., van Haaften Gijs, Houwen Roderick H.J., Müller Thomas, Middendorp Sabine, Boztug Kaan 28 mrt 2018, In: Gastroenterology. 155 , p. 130-143.e15

Intestinal epithelial cell polarity defects in disease: lessons from microvillus inclusion disease

Schneeberger Kerstin, Roth Sabrina, Nieuwenhuis Edward E. S., Middendorp Sabine feb 2018, In: Disease Models & Mechanisms. 11 12 p.

Chromatin Conformation Links Distal Target Genes to CKD Loci

Brandt Maarten M., Meddens Claartje A., Louzao-Martinez Laura, Van Den Dungen Noortje A.M., Lansu Nico R., Nieuwenhuis Edward E.S., Duncker Dirk J., Verhaar Marianne C., Joles Jaap A., Mokry Michal, Cheng Caroline 1 nov 2017, In: Journal of the American Society of Nephrology. 29 , p. 462-476 15 p.

All Research Output (121)