prof. dr. K.G.M. (K. (Carl) G.M. ) Moons

Full Professor

  • Department of Epidemiology
  • Julius Center Research Program Methodology

prof. dr. K.G.M. (K. (Carl) G.M.  ) Moons


K.G.M. (Carl) Moons is Professor of Clinical Epidemiology at the Julius Center for Health Sciences and Primary Care, UMC Utrecht, Utrecht University, Utrecht, The Netherlands. He is Director of Research of the Julius Center (550 Employees). He headed the research program ‘Research Methodology’ until 2019. 


- MSc in Biomedical Sciences (Radboud University Nijmegen, 1992);

- MSc in Clinical Epidemiology (Erasmus University Rotterdam, 1994)

- PhD in Medicine (Erasmus University Rotterdam, 1996).

Since 2005 full Professor of Clinical Epidemiology at the Julius Center,UMC Utrecht, Utrecht University, Utrecht, The Netherlands.

He was a visiting Professor at the University of Virginia, USA (2002) and at Tokai University, Japan (2005-2010).

He has been a member of various committees, e.g. Netherlands Organization for Scientific Research, Royal Dutch Academy of Sciences, Dutch Health Council, Cochrane Collaboration, and Medical Ethical Committees.

He is principal investigator in numerous international clinical (epidemiology) studies funded by various organisations (EU, NHS, NIH). His experience covers the full range of conduct, data analysis, reporting and dissemination of such studies, varying from studies on the evaluation of medical devices and tests for diagnosis, prognosis, screening and monitoring, to etiological studies and randomised therapeutic trials, to meta-epidemiological studies, both on aggregate and individual participant data. His main focus concerns improving the methods and approaches for evaluation and implementation of medical devices, (bio)markers and prediction models. His major expertise is introducing innovations for the design, conducting, analysis and reporting of evaluations of diagnostic and prognostic tests, devices, (bio)markers and prediction models. Clinical topics include cancer, deep vein thrombosis, stroke, heart failure and peri-operative risk assessment. He teaches graduate and postgraduate students in all aspects of clinical (epidemiological) research design, conducting, analysis and reporting, throughout the world.

Indicators of Research Excellence

Over his career Professor Moons has published over 480 peer-reviewed publications (including scientific papers and book chapters) with >22,000 citations (H index 72, Scopus). He has obtained numerous (methodological and applied) research grants, including large prestigious personal grants (in summary over 10 million euro as co-PI). The (societal) impact of his research record has also been recognised by membership of the Dutch Health Council, Chair of Committee of the Royal Netherlands Academy of Arts and Sciences, membership of numerous committees of Dutch Scientific Organisations, and interviews for national and internal news magazines. He also teaches bachelor, master, post doctoral students in clinical research across the world, including Asia and Africa.


Side Activities

  • Adjunct Professor of Clinical Epidemiology, Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, USA. (since 2005)

    Adjunct Professor of Clinical Epidemiology, Center of Statistics in Medicine, Oxford University, Oxford, UK (since 2017)

    Staff Cochrane Netherlands.

    Member of Cochrane Collaboration; Convenor Cochrane's Prognosis Methods Group; Member of IPD Meta-analysis group and Diagnostic Test Accuracy Group.

    Editor-in-chief BMC Diagnostic and Prognostic Research.

    Member of the Dutch Health Council

    Chair of The Netherlands Implant Side-effects Expertise Center

    Initiator and ambassador of Health Innovation Initiative Holland (Hii Holland)

Fellowship and Awards

  • 2003 VIDI Award        The Netherlands Organisation for Health Research and Development, Role: Principal Investigator, “Diagnostic Prediction Rules; innovative methods to improve their applicability”.

    2008 TOP Grant         The Netherlands Organisation for Health Research and Development, Role: Principal Investigator, "Clinical prediction rules: towards a framework for meta-analysis, validation, and updating"

    2010 VICI Award        The Netherlands Organisation for Health Research and Development, Role: Principal Investigator “A different view on diagnostic research: a framework for studying the  Differential diagnosis and diseases with an imperfect or missing reference test"

Research Output (630)

On the aggregation of published prognostic scores for causal inference in observational studies

Nguyen Tri Long, Collins Gary S., Pellegrini Fabio, Moons Karel G.M., Debray Thomas P.A. 15 mei 2020, In: Statistics in Medicine. 39 , p. 1440-1457 18 p.

Accounting for time-dependent treatment use when developing a prognostic model from observational data:A review of methods

Pajouheshnia Romin, Schuster Noah A., Groenwold Rolf H.H., Rutten Frans H., Moons Karel G.M., Peelen Linda M. 1 feb 2020, In: Statistica Neerlandica. 74 , p. 38-51 14 p.

The cardiovascular risk profile of middle-aged women with polycystic ovary syndrome

Meun Cindy, Gunning Marlise N., Louwers Yvonne, V, Peters Henrike, Roos-Hesselink Jolien, van Lennep Jeanine Roeters, Rueda Ochoa Oscar-Leonel, Appelman Yolande, Lambalk Nils, Boersma Eric, Kavousi Maryam, Fauser Bart C. J. M., Laven Joop S. E., Baart Sara, Benschop Laura, Brouwers Laura, Budde Ricardo, Cannegieter Suzanne, Dam Veerle, Eijkemans Rene, Fauser Bart C. J. M., Ferrari Michel, Franx Arie, de Groot Christianne, Gunning Marlise N., Hoek Annemieke, Koffijberg Erik, Koster Wendy, Kruit Mark, Lagerweij Giske, Laven Joop, Linstra Katie, van der Lugt Aad, Maas Angela, van den Brink Antoinette Maassen, Middeldorp Saskia, Moons Karel G. M., van Rijn Bas, Scheres Luuk, van der Schouw Yvonne T., Steegers Eric, Steegers Regine, Terwindt Gisela, Velthuis Birgitta, Wermer Marieke, Zick Bart, Zoet Gerbrand 1 feb 2020, In: Clinical Endocrinology. 92 , p. 150-158 9 p.

Methods to express intraoperative hypotension exposure in the anaesthesia literature

Vernooij Lisette M., van Klei Wilton A., Moons Karel G.M., van Waes Judith A., Peelen Linda M. 6 jan 2020, In: British Journal of Anaesthesia. 124 , p. e35-e37 3 p.

Calibration:The Achilles heel of predictive analytics

Van Calster Ben, McLernon David J., Van Smeden Maarten, Wynants Laure, Steyerberg Ewout W., Bossuyt Patrick, Collins Gary S., MacAskill Petra, McLernon David J., Moons Karel G.M., Steyerberg Ewout W., Van Calster Ben, Van Smeden Maarten, Vickers Andrew J. 16 dec 2019, In: BMC Medicine. 17

The moral and legal status of Health Care Workers in Cluster Randomized Trials:a response to Weijer and Taljaard

van der Graaf Rieke, van Thiel Ghislaine J.M.W., de Hoop Esther Oomen, Moons Karel G.M., Grobbee Diederick E., van Delden Johannes J.M. dec 2019, In: Journal of Clinical Epidemiology. 116 , p. 146-149 4 p.

Individual participant data meta-analysis of intervention studies with time-to-event outcomes:A review of the methodology and an applied example

de Jong Valentijn M T, Moons Karel G M, Riley Richard D, Smith Catrin Tudur, Marson Anthony G, Eijkemans Marinus J C, Debray Thomas P A 23 nov 2019, In: Research synthesis methods. 11 , p. 148-168 21 p.

Validation and impact of a simplified clinical decision rule for diagnosing pulmonary embolism in primary care:design of the PECAN prospective diagnostic cohort management study

van Maanen Rosanne, Rutten Frans H, Klok Frederikus A, Huisman Menno V, Blom Jeanet W, Moons Karel G M, Geersing Geert-Jan 10 okt 2019, In: BMJ Open. 9

World Health Organization cardiovascular disease risk charts:revised models to estimate risk in 21 global regions

Kaptoge Stephen, Pennells Lisa, De Bacquer Dirk, Cooney Marie Therese, Kavousi Maryam, Stevens Gretchen, Riley Leanne Margaret, Savin Stefan, Khan Taskeen, Altay Servet, Amouyel Philippe, Assmann Gerd, Bell Steven, Ben-Shlomo Yoav, Berkman Lisa, Beulens Joline W., Björkelund Cecilia, Blaha Michael, Blazer Dan G., Bolton Thomas, Bonita Beaglehole Ruth, Brenner Hermann, Brunner Eric J., Casiglia Edoardo, Chamnan Parinya, Choi Yeun Hyang, Chowdry Rajiv, Coady Sean, Crespo Carlos J., Cushman Mary, Dagenais Gilles R., D'Agostino Ralph B., Daimon Makoto, Davidson Karina W., Engström Gunnar, Ford Ian, Gallacher John, Gansevoort Ron T., Gaziano Thomas Andrew, Giampaoli Simona, Grandits Greg, Grimsgaard Sameline, Grobbee Diederick E., Gudnason Vilmundur, Guo Qi, Tolonen Hanna, Humphries Steve, Iso Hiroyasu, Jukema J. Wouter, Moons Karel G.M. 1 okt 2019, In: The Lancet Global Health. 7 , p. e1332-e1345

Interim PET-results for prognosis in adults with hodgkin lymphoma:A systematic review and meta-analysis of prognostic factor studies

Aldin Angela, Umlauff Lisa, Estcourt Lise J., Collins Gary, Moons Karel G.M., Engert Andreas, Kobe Carsten, Tresckow Bastian von, Haque Madhuri, Foroutan Farid, Kreuzberger Nina, Trivella Marialena, Skoetz Nicole 16 sep 2019, In: Cochrane Database of Systematic Reviews. 2019

All Research Output (630)