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dr. R.C.W. (René) Mandl Associate Professor

  • Psychiatry

R.C.W. Mandl


Research Programs


René C. W. Mandl obtained his Masters degree in Informatics (artificial intelligence) at the University of Amsterdam in 1996, after which he started to work as a scientific programmer at the Department of Psychiatry of the University Medical Center Utrecht. He started his PhD project (part-time) in 2004 and in 2009 he successfully defended his PhD thesis titled: “Tract-based analysis in schizophrenia: Measuring structure and function along white matter tracts”. Currently he holds a permanent position as an associate professor (research) at the Department of Psychiatry and his research expertise includes diffusion-weighted imaging, structural MRI, functional MRI, MR spectroscopy and the development of new analysis methods.He also worked from 2014 until 2019 as senior researcher (part time) at the CNSR, Psychiatric Center Glostrup, Denmark. He is involved in several international collaborations such as YOUTH, ENIGMA, and TACTICS. 

Research line

New analysis methods for (ultra-) high field MRI in psychiatric research

Most recent key publications

1.        Nuninga JO, Mandl RCW, Boks MP, et al. Volume increase in the dentate gyrus after electroconvulsive therapy in depressed patients as measured with 7T. Mol Psychiatry. 2019. doi:10.1038/s41380-019-0392-6

2.        Legind CS, Broberg BV, Mandl RCW, et al. Heritability of cerebral glutamate levels and their association with schizophrenia spectrum disorders: a (1)[H]-spectroscopy twin study. Neuropsychopharmacology. 2019;44(3):581-589. doi:10.1038/s41386-018-0236-0

3.        Gangadin SS, Nasib LG, Sommer IEC, Mandl RCW. MRI investigation of immune dysregulation in schizophrenia. Curr Opin Psychiatry. 2019. doi:10.1097/yco.0000000000000498

4.        Ferguson B, Petridou N, Fracasso A, et al. Detailed T1-Weighted Profiles from the Human Cortex Measured in Vivo at 3 Tesla MRI. Neuroinformatics. 2018:1-16.

5.        Jessen K, Mandl RCW, Fagerlund B, et al. Patterns of Cortical Structures and Cognition in Antipsychotic-Naïve Patients With First-Episode Schizophrenia: A Partial Least Squares Correlation Analysis. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. 2018.

Research Output (89)

MRI investigation of immune dysregulation in schizophrenia

Gangadin Shiral S, Nasib Lyliana G, Sommer Iris E C, Mandl René C W mei 2019, In: Current Opinion in Psychiatry. 32 , p. 164-169 6 p.


Legind Christian, Broberg Brian, Brouwer Rachel, Mandl Rene, Ebdrup Bjorn H., Anhoj Simon, Jensen Maria H., Hilker Rikke Prime, Fagerlund Birgitte, Pol Hilleke Hulshoff, Glenthoj Birte, Rostrup Egill apr 2019, In: Schizophrenia Bulletin. 45 , p. S311-S311

Heritability of Cerebral Blood Flow and the Correlation to Schizophrenia Spectrum Disorders:A Pseudo-continuous Arterial Spin Labeling Twin Study

Legind Christian S, Broberg Brian V, Brouwer Rachel, Mandl René C W, Ebdrup Bjørn H, Anhøj Simon J, Jensen Maria H, Hilker Rikke, Fagerlund Birgitte, Hulshoff Pol Hilleke E, Glenthøj Birte Y, Rostrup Egill 18 feb 2019, In: Schizophrenia Bulletin. 45 , p. 1231-1241 11 p.

Investigating the factors underlying adaptive functioning in autism in the EU-AIMS Longitudinal European Autism Project

Tillmann Julian, Caceres Antonia San Jose, Chatham Chris H., Crawley Daisy, Holt Rosemary, Oakley Bethany, Banaschewski Tobias, Baron-Cohen Simon, Boelte Sven, Buitelaar Jan K., Durston Sarah, Ham Lindsay, Loth Eva, Simonoff Emily, Spooren Will, Murphy Declan G., Charman Tony, Ahmad Jumana, Ambrosino Sara, Auyeung Bonnie, Baumeister Sarah, Beckmann Christian, Bourgeron Thomas, Bours Carsten, Brammer Michael, Brandeis Daniel, Brogna Claudia, de Bruijn Yvette, Chakrabarti Bhismadev, Cornelissen Ineke, Dell'Acqua Flavio, Dumas Guillaume, Ecker Christine, Faulkner Jessica, Frouin Vincent, Garces Pilar, Goyard David, Hayward Hannah, Hipp Joerg, Johnson Mark H., Jones Emily J. H., Kundu Prantik, Lai Meng-Chuan, D'ardhuy Xavier Liogier, Lombardo Michael, Lythgoe David J., Mandl Rene, Mason Luke, Meyer-Lindenberg Andreas, Oranje Bob 11 feb 2019, In: Autism Research. 12 , p. 645-657

Interhemispheric connectivity and hemispheric specialization in schizophrenia patients and their unaffected siblings

Chang Xiao, Collin Guusje, Mandl Rene C. W., Cahn Wiepke, Kahn Rene S. 7 jan 2019, In: Neuroimage: Clinical [E]. 21

Altered Connectivity Between Cerebellum, Visual, and Sensory-Motor Networks in Autism Spectrum Disorder:Results from the EU-AIMS Longitudinal European Autism Project

Oldehinkel Marianne, Mennes Maarten, Marquand Andre, Charman Tony, Tillmann Julian, Ecker Christine, Dell'Acqua Flavio, Brandeis Daniel, Banaschewski Tobias, Baumeister Sarah, Moessnang Carolin, Baron-Cohen Simon, Holt Rosemary, Bölte Sven, Durston Sarah, Kundu Prantik, Lombardo Michael V., Spooren Will, Loth Eva, Murphy Declan G.M., Beckmann Christian F., Buitelaar Jan K., Ahmad Jumana, Ambrosino Sara, Auyeung Bonnie, Bourgeron Thomas, Bours Carsten, Brammer Michael, Brogna Claudia, de Bruijn Yvette, Chakrabarti Bhismadev, Cornelissen Ineke, Crawley Daisy, Dumas Guillaume, Faulkner Jessica, Frouin Vincent, Garcés Pilar, Goyard David, Ham Lindsay, Hayward Hannah, Hipp Joerg, Johnson Mark H., Jones Emily J.H., Lai Meng Chuan, Liogier D'ardhuy Xavier, Lythgoe David J., Mandl René, Mason Luke, Meyer-Lindenberg Andreas, Oranje Bob, 1 jan 2019, In: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. 4 , p. 260-270 11 p.

Immediate and long-term effects of bilateral electroconvulsive therapy on cognitive functioning in patients with a depressive disorder

Nuninga Jasper O., Claessens Thomas F.I., Somers Metten, Mandl René, Nieuwdorp Wendy, Boks Marco P., Bakker Steven, Begemann Marieke J.H., Heringa Sophie, Sommer Iris E.C. 1 okt 2018, In: Journal of Affective Disorders. 238 , p. 659-665 7 p.

Minimum spanning tree analysis of the human connectome

van Dellen Edwin, Sommer Iris E., Bohlken Marc M., Tewarie Prejaas, Draaisma Laurijn, Zalesky Andrew, Di Biase Maria, Brown Jesse A., Douw Linda, Otte Willem M., Mandl René C.W., Stam Cornelis J. jun 2018, In: Human Brain Mapping. 39 , p. 2455-2471

EU-AIMS Longitudinal European Autism Project (LEAP):The autism twin cohort

Isaksson Johan et al. 13 apr 2018, In: Molecular Autism. 9


Legind Christian, Broberg Brian, Mandl Rene, Brouwer Rachel, Anhoj Simon, Hilker Rikke, Jensen Maria H., McGuire Philip, Pol Hilleke E. Hulshoff, Fagerlund Birgitte, Rostrup Egill, Glenthoj Birte apr 2018, In: Schizophrenia Bulletin. 44 , p. S83-S83

All Research Output (89)
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