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prof. dr. W. (Wiepke) Cahn

Full Professor

  • Psychiatry

prof. dr. W. (Wiepke) Cahn

Research Programs

Biography

Prof. Wiepke Cahn has been a research psychiatrist at the University Medical Center Utrecht since 1996. In 2003 she obtained her PhD titled ‘brain morphology during the early course of schizophrenia’. She has set up various (multicenter) research projects, including GROUP. She has been chief psychiatrist for the schizophrenia program at the UMCUtrecht and project manager for the Utrecht Youth Cohort. Currently she is heading the ‘body & life’ clinic at the department of psychiatry. In 2016 she was appointed professor of psychiatry. Her research interest is the physical (ill-)health in psychiatric disorders.

Wiepke Cahn is vice-president of the Dutch Psychiatric Association. She has authored more than 200 papers and book chapters and has been chief editor of ‘handboek schizofrenie’. Her non-research-based activities consist of treating patients and their families with psychotic and bipolar disorders.

Research Line

Physical health in psychiatric disorders

Most recent key publications

  1. Liemburg EJ, Bruins J, van Beveren N, Islam MA, Alizadeh BZ; GROUP investigators. Cannabis and a lower BMI in psychosis: What is the role of AKT1? Schizophr Res. 2016 Oct;176(2-3):95-9.
  2. de Nijs J, Pet MA; GROUP Investigators.. Metabolic syndrome in schizophrenia patients associated with poor premorbid school performance in early adolescence. Acta Psychiatr Scand. 2016 Apr;133(4):289-97.
  3. Scheewe TW, Backx FJ, Takken T, Jörg F, van Strater AC, Kroes AG, Kahn RS, Cahn W. Exercise therapy improves mental and physical health in schizophrenia: a randomised controlled trial. Acta Psychiatr Scand. 2013 Jun;127(6):464-73.
  4. Welie H, Derks EM, Verweij KH, de Valk HW, Kahn RS, Cahn W. The prevalence of diabetes mellitus is increased in relatives of patients with a non-affective psychotic disorder. Schizophr Res. 2013 Feb;143(2-3):354-7.
  5. Cahn W, Ramlal D, Bruggeman R, de Haan L, Scheepers FE, van Soest MM, Assies J, Slooff CJ. [Prevention and treatment of somatic complications arising from the use of antipsychotics]. Tijdschr Psychiatr. 2008;50(9):579-91.

 

Side Activities

  • GGz Breburg Supervisory Board

    Full Professor, Altrecht Science

Fellowship and Awards

    • Genetic Risk and Outcome of Psychosis (GROUP project) – i.s.m. AMC, UMCG en Universiteit van Maastricht
    • Topfit project – i.s.m. met sportgeneeskunde
    • GRUMPY or Depressed – i.s.m. de sociale faculteit UU
    • Adding in- and outpatient parmacotherapeutic treatment information – i.s.m. de faculteit farmaceutische wetenschappen
    • International panel study on the appropriate pharmacological management of early schizophrenia – RAND/UCLA study

Research Output (267)

Evolutionary modifications in human brain connectivity associated with schizophrenia

van den Heuvel Martijn P, Scholtens Lianne H, de Lange Siemon C, Pijnenburg Rory, Cahn Wiepke, van Haren Neeltje E M, Sommer Iris E, Bozzali Marco, Koch Kathrin, Boks Marco P, Repple Jonathan, Pievani Michela, Li Longchuan, Preuss Todd M, Rilling James K 14 nov 2019, In: Brain : a journal of neurology. 142 , p. 3991-4002 12 p.

Genetic architecture of subcortical brain structures in 38,851 individuals

Satizabal Claudia L., Adams Hieab H.H., Hibar Derrek P., White Charles C., Knol Maria J., Stein Jason L., Scholz Markus, Sargurupremraj Muralidharan, Jahanshad Neda, Roshchupkin Gennady V., Smith Albert V., Bis Joshua C., Jian Xueqiu, Luciano Michelle, Hofer Edith, Teumer Alexander, van der Lee Sven J., Yang Jingyun, Yanek Lisa R., Lee Tom V., Li Shuo, Hu Yanhui, Koh Jia Yu, Eicher John D., Desrivières Sylvane, Arias-Vasquez Alejandro, Chauhan Ganesh, Athanasiu Lavinia, Rentería Miguel E., Kim Sungeun, Hoehn David, Armstrong Nicola J., Chen Qiang, Holmes Avram J., den Braber Anouk, Kloszewska Iwona, Andersson Micael, Abramovic Lucija, Bohlken Marc M., Klein Marieke, Boks Marco P., van Eijk Kristel R., Cahn Wiepke, Hulshoff Pol Hilleke E., Ikram M. Kamran, Brouwer Rachel M., Kahn René S., Ophoff Roel A., van Haren Neeltje E.M., Schmidt Reinhold, 1 nov 2019, In: Nature Genetics. 51 , p. 1624-1636 13 p.

Prevalence of metabolic syndrome and its associated risk factors in an African–Caribbean population with severe mental illness

de Caluwé Laura, van Buitenen Nora, Gelan Petra J., Crunelle Cleo L., Thomas Roeland, Casseres Sharon, Matthys Frieda, van Harten Peter, Cahn Wiepke 1 nov 2019, In: Psychiatry Research. 281

ASSESSING CAUSAL LINKS BETWEEN METABOLIC TRAITS, INFLAMMATION AND SCHIZOPHRENIA: A UNIVARIABLE AND MULTIVARIABLE BIDIRECTIONAL MENDELIAN RANDOMIZATION STUDY

Lin Bochao, Alkema Anne, Zinkstok Janneke, Lars Libuda, Hebebrand Johannes, Antel Jochen, Hinney Anke, Cahn Wiepke, Roger Adan, Luykx Jurjen okt 2019, In: European Neuropsychopharmacology. 29 , p. S211-S211

Assessing causal links between metabolic traits, inflammation and schizophrenia:a univariable and multivariable, bidirectional Mendelian-randomization study

Lin Bochao D., Alkema Anne, Peters Triinu, Zinkstok Janneke, Libuda Lars, Hebebrand Johannes, Antel Jochen, Hinney Anke, Cahn Wiepke, Adan Roger, Luykx Jurjen J. 31 aug 2019, In: International Journal of Epidemiology. 48 , p. 1505-1514 10 p.

Shared vulnerability for connectome alterations across psychiatric and neurological brain disorders

de Lange Siemon C., Scholtens Lianne H., van den Berg Leonard H., Boks Marco P., Bozzali Marco, Cahn Wiepke, Dannlowski Udo, Durston Sarah, Geuze Elbert, van Haren Neeltje E.M., Hillegers Manon H.J., Koch Kathrin, Jurado María Ángeles, Mancini Matteo, Marqués-Iturria Idoia, Meinert Susanne, Ophoff Roel A., Reess Tim J., Repple Jonathan, Kahn René S., van den Heuvel Martijn P., 5 aug 2019, In: NATURE HUMAN BEHAVIOUR. 3 , p. 988-998 11 p.

Exploration of Shared Genetic Architecture Between Subcortical Brain Volumes and Anorexia Nervosa

Walton E., Hibar D., Yilmaz Z., Jahanshad N., Cheung J., Batury V. -L., Seitz J., Bulik C. M., Thompson P. M., Ehrlich Stefan, Hibar Derrek P., Stein Jason L., Renteria Miguel E., Arias-Vasquez Alejandro, Desrivieres Sylvane, Jahanshad Neda, Toro Roberto, Wittfeld Katharina, Abramovic Lucija, Andersson Micael, Aribisala Benjamin S., Armstrong Nicola J., Bernard Manon, Bohlken Marc M., Boks Marco P., Bralten Janita, Brown Andrew A., Chakravarty M. Mallar, Chen Qiang, Ching Christopher R. K., Cuellar-Partida Gabriel, Den Braber Anouk, Giddaluru Sudheer, Goldman Aaron L., Grimm Oliver, Guadalupe Tulio, Hass Johanna, Woldehawariat Girma, Klein Marieke, van Eijk Kristel R., Cahn Wiepke, Kahn Rene S., van Haren Neeltje E. M., Brouwer Rachel M., Pol Hilleke E. Hulshoff, Ophoff Roel, Adan Roger, Kas Martien, Koeleman Bobby, Ophoff Roel, 1 jul 2019, In: Molecular Neurobiology. 56 , p. 5146-5156 11 p.

The Association Between Familial Risk and Brain Abnormalities Is Disease Specific:An ENIGMA-Relatives Study of Schizophrenia and Bipolar Disorder

de Zwarte Sonja M C, Brouwer Rachel M, Agartz Ingrid, Alda Martin, Aleman André, Alpert Kathryn I, Bearden Carrie E, Bertolino Alessandro, Bois Catherine, Bonvino Aurora, Bramon Elvira, Buimer Elizabeth E L, Cahn Wiepke, Cannon Dara M, Cannon Tyrone D, Caseras Xavier, Castro-Fornieles Josefina, Chen Qiang, Chung Yoonho, De la Serna Elena, Di Giorgio Annabella, Doucet Gaelle E, Eker Mehmet Cagdas, Erk Susanne, Fears Scott C, Foley Sonya F, Frangou Sophia, Frankland Andrew, Fullerton Janice M, Glahn David C, Goghari Vina M, Goldman Aaron L, Gonul Ali Saffet, Gruber Oliver, de Haan Lieuwe, Hajek Tomas, Hawkins Emma L, Heinz Andreas, Hillegers Manon H J, Hulshoff Pol Hilleke, Hultman Christina M, Ingvar Martin, Johansson Viktoria, Jönsson Erik G, Kane Fergus, Kempton Matthew J, Koenis Marinka M G, van Os Jim, Kahn René, van Haren Neeltje E M, 13 jun 2019, In: Biological Psychiatry. 86 , p. 545-556 12 p.

GWAS of Suicide Attempt in Psychiatric Disorders and Association With Major Depression Polygenic Risk Scores

Mullins Niamh, Bigdeli Tim B, Børglum Anders D, Coleman Jonathan R I, Demontis Ditte, Mehta Divya, Power Robert A, Ripke Stephan, Stahl Eli A, Starnawska Anna, Anjorin Adebayo, Corvin Aiden, Sanders Alan R, Forstner Andreas J, Reif Andreas, Koller Anna C, Świątkowska Beata, Baune Bernhard T, Müller-Myhsok Bertram, Penninx Brenda W J H, Pato Carlos, Zai Clement, Rujescu Dan, Hougaard David M, Quested Digby, Levinson Douglas F, Binder Elisabeth B, Byrne Enda M, Agerbo Esben, Streit Fabian, Mayoral Fermin, Bellivier Frank, Degenhardt Franziska, Breen Gerome, Morken Gunnar, Turecki Gustavo, Rouleau Guy A, Grabe Hans J, Völzke Henry, Jones Ian, Giegling Ina, Agartz Ingrid, Melle Ingrid, Lawrence Jacob, Walters James T R, Strohmaier Jana, Boks Marco, Kahn René S, Ophoff Roel A, Cahn Wiepke, 5 jun 2019, In: American Journal of Psychiatry. 176 , p. 651-660 10 p.

Community housing: functional outcome of severe mental illness is associated with the personality traits of the case manager

Lodder Mandy, Schrijvers A. J. P., de Leeuw J. R. J., Brouwer R. M., Cahn W. 3 jun 2019, In: HOUSING CARE AND SUPPORT. 22 , p. 106-113 8 p.

All Research Output (267)